Over-use of antibiotics and antifungals and consequent drug resistance leaves the application and success of current antimicrobial therapies ever more limited. Global healthcare is facing an unprecedented crisis with the current and predicted future unmet clinical need for effective, safe and resistance-free therapies to combat bacterial, fungal, viral and other infectious diseases and conditions. Chemistry-led approaches have failed to solve this problem and so NovaBiotics has employed a very different approach, informed or rational drug design, with nature as the template for a totally novel class of antimicrobial therapies that have the potential to meet the need for safer, more effective antifungal and antibacterial treatments.